Pyrrolysine | Introduction | History | Applications.....

 Pyrrolysine | Introduction | History | Applications....

 Pyrrolysine Amino Acid

Introduction-

Pyrrolysine symbol Pyl or O encoded by the amber stop codon UAG. It is contain α-amino acid that is used in the biosynthesis of proteins in some methanogenic archaea and bacteria; it is not present in humans. It contains an α-amino group, a carboxylic acid group. Its pyrroline side-chain is similar to that of lysine in being basic and positively charged at neutral pH.

Structure-

Properties-

Formula: C₁₂H₂₁N₃O₃

Molar mass: 255.313 g/mol

ChemSpider ID: 4574156

Classification: Amino Acid

3D model (JSmol): Interactive image; Zwitterion: Interactive image

ChEBI ID: 58499

History-

Joseph Krzycki and Michael Chan were the leaders and faculty who with their research team discovered the 22nd amino acid, L-pyrrolysine, in 2002. The 22nd is only found in organisms which use methylamines as energy sources (methanogenic archaea and bacterium).

 

Function-

Pyrrolysine has the structure of lysine with the ^ɛN in amide linkage with a pyrroline ring.

The reactivity of the electrophilic imine bond is the basis for the proposed function of pyrrolysine in activating and optimally orienting methylamine for methyl transfer to the cobalt ion of a cognate corrinoid protein.

 

 

 

 

 

 SUBSCRIBE FOR MORE INFORMATION........!